Diabetes-Old Therapies Revisited
ثبت نشده
چکیده
Today, there are many therapeutic options for the treatment of type 2 Diabetes, which means that therapeutic decision making has become increasingly challenging and complex. With the recent introduction in clinical practice of new classes, with different mechanisms of action, what is the role of the older drugs? This article reviews these drugs, with recently published data update. Today, recommendations are not based on a simple algoritm, but in a patient centered approach. Besides the phenotypic heterogeneity of patients with type 2 diabetes, there is also a great diversity in response to treatment. This concept of personalized medicine has changed in recent years. The new era of personalized medicine evolves in order to identify molecular and clinical signs that can predict therapeutic response, reducing uncertainty in decision making. The “old” drugs may resurface, with more precise indications, in selected groups of patients.
منابع مشابه
A 70-year-old male with peripheral neuropathy, ataxia and antigliadin antibodies shows improvement in neuropathy, but not ataxia, after intravenous immunoglobulin and gluten-free diet
This is a case of a 70-year-old man with severe peripheral neuropathy, type 2 diabetes and progressively worsening cerebellar ataxia. He was found to have circulating antigliadin and antireticulin antibodies compatible with celiac disease in the absence of intestinal pathology. The peripheral neuropathy improved with a gluten-free diet, antioxidants and intravenous immunoglobulin, whereas the a...
متن کاملWater balance disorders after neurosurgery: the triphasic response revisited
Water balance disorders after neurosurgery are well recognized, but detailed reports of the triphasic response are scarce. We describe a 55-year-old woman, who developed the triphasic response with severe hyper- and hyponatraemia after resection of a suprasellar meningioma. The case illustrates how sudden and dramatic the changes in water balance after neurosurgery can be. The biochemical profi...
متن کاملNew Methods in Exploring Old Topics: Case Studying Brittle Diabetes in the Family Context
BACKGROUND In questing for a more refined quantitative research approach, we revisited vector autoregressive (VAR) modeling for the analysis of time series data in the context of the so far poorly explored concept of family dynamics surrounding instable diabetes type 1 (or brittle diabetes). METHOD We adopted a new approach to VAR analysis from econometrics referred to as the optimized multiv...
متن کاملتجارب بیماران مبتلا به دیابت نوع دو در استفاده از انسولین
Background: Given the recognizing the determinants of medication adherence in diabetic patients is necessary to design appropriate interventions, the aim of this study was to clarification experiences of parsons with type II diabetes in terms of insulin use. Methods: This qualitative study was conducted on 22 patients with type II diabetes who were referred to Glands Clinic of Firozgar Hospita...
متن کامل